Rheumatoid factor measures agglutination between which immunoglobulins?

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Study for the CMS II Rheumatology E1 Test. Boost your knowledge with flashcards and multiple choice questions. Each question includes helpful hints and explanations. Prepare to excel on your exam!

Multiple Choice

Rheumatoid factor measures agglutination between which immunoglobulins?

Explanation:
Rheumatoid factor is an IgM autoantibody that targets the Fc region of IgG. In a typical RF test, IgM RF in the patient’s serum binds to IgG (often coating the test particles), cross-linking IgG molecules and causing agglutination. This means the interaction being detected is between IgM (the RF antibody) and IgG (the target IgG). The other pairings don’t reflect the usual RF mechanism, which is why the correct interaction is IgM with IgG.

Rheumatoid factor is an IgM autoantibody that targets the Fc region of IgG. In a typical RF test, IgM RF in the patient’s serum binds to IgG (often coating the test particles), cross-linking IgG molecules and causing agglutination. This means the interaction being detected is between IgM (the RF antibody) and IgG (the target IgG). The other pairings don’t reflect the usual RF mechanism, which is why the correct interaction is IgM with IgG.

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