Which adverse effect is commonly associated with pegloticase therapy aside from anaphylaxis?

Which adverse effect is commonly associated with pegloticase therapy aside from anaphylaxis?

• A. Gout flares
• B. Nephrolithiasis
• C. Hypertension
• D. Hepatotoxicity

Answer: (A)

Rapid reduction of serum uric acid with pegloticase can mobilize urate crystals from joints and tophi, provoking an acute inflammatory response. This makes gout flares the most common adverse effect seen after the risk of anaphylaxis, as urate crystals are suddenly released and trigger joint inflammation. To minimize these flares, clinicians often use prophylaxis with colchicine or NSAIDs when starting pegloticase. Nephrolithiasis is not typically driven by lowering urate and thus is not expected to rise with pegloticase; hypertension and hepatotoxicity are not characteristic adverse effects of this therapy.

Rapid reduction of serum uric acid with pegloticase can mobilize urate crystals from joints and tophi, provoking an acute inflammatory response. This makes gout flares the most common adverse effect seen after the risk of anaphylaxis, as urate crystals are suddenly released and trigger joint inflammation. To minimize these flares, clinicians often use prophylaxis with colchicine or NSAIDs when starting pegloticase. Nephrolithiasis is not typically driven by lowering urate and thus is not expected to rise with pegloticase; hypertension and hepatotoxicity are not characteristic adverse effects of this therapy.