Which agent is an IL-1 receptor antagonist?

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Study for the CMS II Rheumatology E1 Test. Boost your knowledge with flashcards and multiple choice questions. Each question includes helpful hints and explanations. Prepare to excel on your exam!

Multiple Choice

Which agent is an IL-1 receptor antagonist?

Explanation:
Blocking IL-1 signaling is the key idea. Anakinra is a recombinant IL-1 receptor antagonist that binds to the IL-1 receptor, preventing IL-1 alpha and IL-1 beta from signaling and thus reducing inflammation. This distinguishes it from the others: Tocilizumab blocks the IL-6 receptor, Rituximab depletes CD20+ B cells, and Abatacept interferes with T cell activation by inhibiting CD28 costimulation. Therefore, the agent that acts as an IL-1 receptor antagonist is Anakinra.

Blocking IL-1 signaling is the key idea. Anakinra is a recombinant IL-1 receptor antagonist that binds to the IL-1 receptor, preventing IL-1 alpha and IL-1 beta from signaling and thus reducing inflammation. This distinguishes it from the others: Tocilizumab blocks the IL-6 receptor, Rituximab depletes CD20+ B cells, and Abatacept interferes with T cell activation by inhibiting CD28 costimulation. Therefore, the agent that acts as an IL-1 receptor antagonist is Anakinra.

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