Which genetic marker is associated with psoriatic arthritis?

Which genetic marker is associated with psoriatic arthritis?

• A. HLA-B27
• B. HLA-DR4
• C. HLA-B51
• D. HLA-A3

Answer: (A)

Genetic predisposition in psoriatic arthritis shows a strong link with HLA-B27, a class I MHC molecule. This marker is frequently found in patients with psoriatic arthritis, especially those with axial involvement or spondyloarthropathy features. The association helps explain why some patients develop spine-related symptoms alongside their psoriatic arthritis. The other markers point to different diseases—for example, HLA-DR4 is more tied to rheumatoid arthritis, HLA-B51 to Behçet disease, and HLA-A3 is not a prominent driver of psoriatic arthritis. Therefore, HLA-B27 is the genetic marker most consistently associated with psoriatic arthritis.

Genetic predisposition in psoriatic arthritis shows a strong link with HLA-B27, a class I MHC molecule. This marker is frequently found in patients with psoriatic arthritis, especially those with axial involvement or spondyloarthropathy features. The association helps explain why some patients develop spine-related symptoms alongside their psoriatic arthritis. The other markers point to different diseases—for example, HLA-DR4 is more tied to rheumatoid arthritis, HLA-B51 to Behçet disease, and HLA-A3 is not a prominent driver of psoriatic arthritis. Therefore, HLA-B27 is the genetic marker most consistently associated with psoriatic arthritis.